Abstract #2312

BBN-assembled Gadolinium oxide nanoprobe for targeted bimodal imaging in vitro and in vivo

Danting Cui¹, Xiaodan Lu¹, Chenggong Yan¹, Xiang Liu¹, Yingjie Mei², Meirong Hou¹, Yikai Xu¹, and Ruiying Liu³

¹Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, ²Philips Healthcare, Guangzhou, China, People's Republic of, ³School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China, People's Republic of

Bombesin (BBN) is a peptide exhibiting high affinity for the gastrin-releasing peptide receptor (GRPr), To develop a BBN-assembled nanoprobe based on Gd2O3 was efficent for earlier tumor detection. Gd2O3 was conjugated with 5(6)-carboxyfluorescein and bombesin for MR/optical bimodal imaging of GRPr positive tumor. Gd2O3-FI-PEG NPs without bombesin-modified NPs were tested as non-targeted control. MRI and opitical imaging in vitro and vivo confirmed BBN-assembled Gd2O3 nanoprobe exhibited better binding affinity to GRPr positive tumor than the control group. The nanoprobe may provide opportunities to further biomedical application.

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