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Abstract #2312

BBN-assembled Gadolinium oxide nanoprobe for targeted bimodal imaging in vitro and in vivo

Danting Cui1, Xiaodan Lu1, Chenggong Yan1, Xiang Liu1, Yingjie Mei2, Meirong Hou1, Yikai Xu1, and Ruiying Liu3

1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, 2Philips Healthcare, Guangzhou, China, People's Republic of, 3School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China, People's Republic of

Bombesin (BBN) is a peptide exhibiting high affinity for the gastrin-releasing peptide receptor (GRPr), To develop a BBN-assembled nanoprobe based on Gd2O3 was efficent for earlier tumor detection. Gd2O3 was conjugated with 5(6)-carboxyfluorescein and bombesin for MR/optical bimodal imaging of GRPr positive tumor. Gd2O3-FI-PEG NPs without bombesin-modified NPs were tested as non-targeted control. MRI and opitical imaging in vitro and vivo confirmed BBN-assembled Gd2O3 nanoprobe exhibited better binding affinity to GRPr positive tumor than the control group. The nanoprobe may provide opportunities to further biomedical application.

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