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Abstract #2314

­Short-lived mesenchymal stem cells accelerate healing of acid skin burns – an MRI cell tracking study using iron oxide, fluorine and bioluminescence imaging

Ghulam Muhammad1,2, Jiadi Xu3, Jeff W.M. Bulte1, Anna Jablonska1, Piotr Walczak1,4, and Miroslaw Janowski5

1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2Stem Cell Laboratory, University of the Punjab, Lahore, Pakistan, 3F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 4Department of Radiology, University of Warmia and Mazury, Olsztyn, Poland, 5Johns Hopkins University, Baltimore, MD, United States

Incidence of acid burns due to accidents and attacks is on the rise and mesenchymal stem cell transplantation is a promising therapeutic strategy. Cell tracking makes treatment more precise. We have compared two MRI tracking strategies: SPIO nanoparticles-based 1H MRI and 19F nanoemulsion “hot-spot” MRI. Bioluminescence imaging was used as a reference standard for monitoring cell survival. Susceptibility artifacts due to skin injury compromised the interpretation of 1H imaging, while 19F MRI was capable of providing information on cell location and survival. The SPIO nanoparticles and fluorine nanoemulsion had no detrimental effect on the therapeutic activity and survival of MSCs.

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