Abstract #2320

Longitudinal MEMRI Characterization of a Novel Mouse Medulloblastoma Model

Harikrishna Rallapalli¹, Eugenia Rafaela Volkova¹, I-Li Tan², Alexandre Wojcinski², Alexandra L Joyner², and Daniel H Turnbull¹

¹Skirball Institute and Radiology, New York University School of Medicine, New York, NY, United States, ²Developmental Biology, Sloan Kettering Institute, New York, NY, United States

In this work, we describe a powerful longitudinal Manganese-enhanced magnetic resonance imaging (MEMRI) strategy to characterize a novel mouse medulloblastoma model. An activated Smoothened mutation was engineered to induce proliferative growth in the cerebellum. Lesions were monitored using MEMRI up to postnatal day P100, and 3D tumors were segmented for quantitative volumetric analysis. Qualitative analysis has shown a ~50% chance of regression overall (n=21), and preliminary quantitation has suggested a combined progression/regression growth model. With this model, we aim to guide diagnostic decisions from early timepoints and quantify therapeutic efficacy.

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