Abstract #2328

Development of Calibrationless Parallel Imaging Methods for Clinical Hyperpolarized Carbon-13 MRI Studies

Yesu Feng¹, Jeremy Gordon¹, Peter Shin¹, Cornelius von Morze¹, Michael Lustig², Peder E.Z. Larson¹, Michael A. Ohliger¹, Lucas Carvajal¹, James Tropp³, John M Pauly⁴, and Daniel B. Vigneron¹

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²EECS, UC Berkeley, Berkeley, CA, United States, ³GE Healthcare, Fremont, CA, United States, ⁴Electrical Engineering, Stanford, Stanford, CA, United States

Hyperpolarized (HP) 13C imaging requires fast data acquisition due to the fast T1 relaxation. Parallel imaging methods are well suited for acceleration of data acquisition, yet conventional parallel imaging schemes require explicit calibration of coil sensitivity which presents significant challenge to HP 13C imaging. In this study, a calibrationless parallel imaging method was tested and applied to HP 13C MRI. A 2-fold acceleration was achieved when this technique was applied together with a 2D EPI readout. This strategy is being extended for 3D HP 13C EPI for improved volumetric coverage and better temporal resolution for future clinical studies.

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