Abstract #2362

Neurochemical Changes in Thalamus and Midbrain of Patients with Obstructive Sleep Apnea Syndrome using Accelerated Echo Planer J-resolved Spectroscopic Imaging

Manoj Kumar Sarma¹, Paul Michael Macey², Rajakumar Nagarajan¹, Ravi Aysola³, and M. Albert Thomas¹

¹Radiological Sciences, UCLA School of Medicine, Los angeles, Los Angeles, CA, United States, ²School of Nursing, UCLA School of Medicine, Los angeles, Los Angeles, CA, United States, ³Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los angeles, Los Angeles, CA, United States

Obstructive sleep apnea syndrome (OSAS), which have many comorbidities including hypertension and other cardiovascular diseases, leads to autonomic, cognitive, and affective abnormalities. The thalamus, and midbrain are key structures that serve such functions through critical relays in nuclei but the status of this region is unclear OSAS. Here, we examined neurochemical changes in the thalamus and midbrain of OSAS patients to better understand the nature of tissue changes using compressed sensing based 4D echo-planar J-resolved spectroscopic imaging (EP-JRESI) and prior knowledge fitting (ProFit) algorithm for metabolite quantification. We observed significantly increased mI/Cr in midbrain and bilateral thalamus. Significantly increased Glx/Cr, Glu/Cr was found in right thalamus and midbrain, and decreased tNAA/Cr, NAA/Cr in left thalamus and midbrain respectively. Thalamus showed significantly reduced tCho/Cr bilaterally. We also found significantly decreased GPC/Cr, increased Gln/Cr, Asc/Cr in right thalamus and increased Asc/Cr in midbrain. The findings will help to explain structural brain changes in OSAS. Most of these metabolites can be manipulated through pharmacological approaches, and could serve as a biomarker of any possible intervention.

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