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Abstract #2370

Novel Triple-refocusing 1H MRS at 3T for detection of GABA in human brain in vivo

Zhongxu An1, Sandeep Ganji1, Vivek Tiwari1, and Changho Choi1

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Reliable detection of GABA is important for research studies in neuro-psychiatric diseases. In vivo 1H GABA resonances extensively overlap with the neighboring resonances of glutamate and glutamine. We present an optimized single-shot triple-focusing 1H MRS method which fully resolved GABA 2.29-ppm signal at 3T.

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Abstract