Abstract #2370

Novel Triple-refocusing 1H MRS at 3T for detection of GABA in human brain in vivo

Zhongxu An¹, Sandeep Ganji¹, Vivek Tiwari¹, and Changho Choi¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Reliable detection of GABA is important for research studies in neuro-psychiatric diseases. In vivo ¹H GABA resonances extensively overlap with the neighboring resonances of glutamate and glutamine. We present an optimized single-shot triple-focusing 1H MRS method which fully resolved GABA 2.29-ppm signal at 3T.

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