Abstract #2403

DRESS localized FAST technique at 7T uncovers the relation between mitochondrial capacity and ATP synthase flux in exercising gastrocnemius medialis muscle

Marjeta Tušek Jelenc^1,2, Marek Chmelík^1,2, Barbara Ukropcová^3,4, Wolfgang Bogner^1,2, Siegfried Trattnig^1,2, Jozef Ukropec⁴, Martin Krššák^1,2,5, and Ladislav Valkovič^1,2,6,7

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Institute of pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia, ⁴Obesity section, Diabetes and Metabolic Disease Laboratory, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁶Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁷University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

The aim of the study was to investigate the relation between the maximum oxidative flux (Q_max), a valid measure of muscular mitochondrial capacity and ATP synthase flux (F_ATP) measured in exercising gastrocnemius medialis muscle in healthy young and elderly subjects. Furthermore, we explored the possibility of direct measurement of both, Q_max and F_{ATP_ex}, in a single experiment. The dynamic experiment consisted of the acquisition of baseline data during two minutes of rest, six minutes of aerobic plantar flexion exercise (during which a 3.5 minutes long FAST measurement was performed), and six minutes of recovery. Our data showed significant correlation between ATP synthase flux in exercising muscle and maximal oxidative flux.

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