Abstract #2413

Magnetic resonance spectroscopy (MRS) of post-traumatic epileptogenesis

Amna Yasmin¹, Olli Gröhn¹, Asla Pitkänen¹, and Riikka Immonen¹

¹Department of Neurobiology, A.I. Virtanen Institute University of Eastern Finland, Kuopio, Finland

Traumatic brain injury (TBI) is the main cause of mortality and morbidity worldwide. Up to 53 % of TBI patients with penetrating head injuries develop epilepsy in later part of life. Unavailability of biomarkers for epileptogensis is a major unmet clinical need, and is the greatest obstacle on the way of developing treatment in patients at risk, e.g., after TBI. Objective of this study is to determine metabolic profile in perilesional cortical area in clinically relevant TBI rat model and correlate MRS findings with EEG and histological outcomes in search for biomarkers. Results: Six out of 13 parameters showed changes at some follow point. Findings of long TBI follow up will help to investigate cellular and molecular mechanisms underlying post-traumatic epileptogenesis and identify reliable biomarkers that could serve as therapeutic targets for the development of new antiepileptogenic and antiseizure compound.

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