Amna Yasmin1, Olli Gröhn1, Asla Pitkänen1, and Riikka Immonen1
Traumatic brain injury (TBI)
is the main cause of mortality and morbidity worldwide. Up to 53 % of TBI
patients with penetrating head injuries develop epilepsy in later part of life.
Unavailability of biomarkers for epileptogensis is a major unmet clinical need,
and is the greatest obstacle on the way of developing treatment in patients at
risk, e.g., after TBI. Objective of
this study is to
determine metabolic profile in perilesional cortical area in clinically
relevant TBI rat model and correlate MRS findings with EEG and histological
outcomes in search for biomarkers. Results:
Six out of 13 parameters showed changes at some follow point. Findings of long TBI follow up will help to investigate cellular and
molecular mechanisms underlying post-traumatic epileptogenesis and identify
reliable biomarkers that could serve as therapeutic targets for the development
of new antiepileptogenic and antiseizure compound.