Abstract #2415

Proton MR Metabolic Profiling in Bodyfluids for differentiation of Meningitis in adults

Tanushri Chatterji¹, Dr. Suruchi Singh², Dr. Manodeep Sen¹, Dr. Ajai Singh³, Prof. Raja Roy², and Dr. J.K Srivastava⁴

¹Microbiology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India, ²Centre of Bio-Medical Research, Lucknow, India, ³Neurology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India, ⁴Amity Institute of Biotechnology, Amity University, Lucknow, India

This study explored diagnostic utility based on the analysis of CSF, serum and urine for differential diagnosis of bacterial (BM) and tubercular meningitis (TBM) in adults using ¹H NMR metabolic profiling.This may render rapid diagnosis of meningitis resulting to the decline of mortality by appropriate and timely treatment regimen. The Discriminant Functional Analysis (DFA) identified acetate, alanine, malonate and choline containing compounds as significant metabolites among case and control. The Orthogonal Signal Correction Principal Component Analysis (OSC-PCA) of significant metabolites clearly differentiated case vs control group in serum and urine samples, while a clear classification could not be obtained for CSF samples.

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