Abstract #2423

Proton MRS monitoring of Atkins-based dietary therapy in patients with glioma

Peter B Barker^1,2, Subechhya Pradhan¹, Yanqin Lin^1,3, Karisa C Schreck⁴, Doris D.M. Lin¹, Jaishri Blakeley^4,5, and Roy E Strowd^5,6

¹Radiology, Johns Hopkins Univ School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Electronic Science, Xiamen University, Xiamen, China, People's Republic of, ⁴Neurology, Johns Hopkins Univ School of Medicine, Baltimore, MD, United States, ⁵Oncology, Johns Hopkins Univ School of Medicine, Baltimore, MD, United States, ⁶Department of Neurology and Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, United States

5 patients with high grade glioma were enrolled in an 8-week dietary therapy program based on the modified Atkin’s diet. Tumor and contralateral brain metabolism was monitored before and after therapy using proton MRS. Significant reductions in contralateral NAA were observed post treatment, as well as increases in acetone in both lesion and contralateral brain. MRS may be useful for monitoring the efficacy of dietary therapy in patients with malignant glioma.

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