The Influence of Pre-load Contrast Agent Dosing Schemes on DSC-MRI Data
Natenael B. Semmineh1, Kelly Gardner1, Jerrold L. Boxerman2, and C. Chad Quarles1
1Imaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States
Brain tumor DSC-MRI
studies can be confounded by T1 and T2*
effects that occur when the contrast agent extravasates. Traditionally a
combination of CA pre-loading and leakage correction techniques are used to minimize
T1 leakage effects, but currently there is no consensus on the most
robust dosing scheme. Using simulations we demonstrate that pre-load dosing
schemes significantly alter blood volume estimates. This computational approach
is being utilized to identify a CA dosing scheme that minimizes total CA dose
and yields robust CBV measures across a range of physical,
physiological and pulse sequence parameters.
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