Abstract #2464

The Influence of Pre-load Contrast Agent Dosing Schemes on DSC-MRI Data

Natenael B. Semmineh¹, Kelly Gardner¹, Jerrold L. Boxerman², and C. Chad Quarles¹

¹Imaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, ²Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States

Brain tumor DSC-MRI studies can be confounded by T₁ and T₂^* effects that occur when the contrast agent extravasates. Traditionally a combination of CA pre-loading and leakage correction techniques are used to minimize T₁ leakage effects, but currently there is no consensus on the most robust dosing scheme. Using simulations we demonstrate that pre-load dosing schemes significantly alter blood volume estimates. This computational approach is being utilized to identify a CA dosing scheme that minimizes total CA dose and yields robust CBV measures across a range of physical, physiological and pulse sequence parameters.

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