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Abstract #2464

The Influence of Pre-load Contrast Agent Dosing Schemes on DSC-MRI Data

Natenael B. Semmineh1, Kelly Gardner1, Jerrold L. Boxerman2, and C. Chad Quarles1

1Imaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States

Brain tumor DSC-MRI studies can be confounded by T1 and T2* effects that occur when the contrast agent extravasates. Traditionally a combination of CA pre-loading and leakage correction techniques are used to minimize T1 leakage effects, but currently there is no consensus on the most robust dosing scheme. Using simulations we demonstrate that pre-load dosing schemes significantly alter blood volume estimates. This computational approach is being utilized to identify a CA dosing scheme that minimizes total CA dose and yields robust CBV measures across a range of physical, physiological and pulse sequence parameters.

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