Cerebral blood flow measurements correlate well in paediatric brain tumour patients using ASL- and DSC-MRI
Jan Novak1,2, Stephanie Withey1,2, Lesley MacPherson3, and Andrew Peet1,2
1Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom, 2Oncology, Birmingham Children's Hospital, Birmingham, United Kingdom, 3Radiology, Birmingham Children's Hospital, Birmingham, United Kingdom
Low grade paediatric brain tumours
are increasingly being targeted by anti-vasculature therapies. It is therefore of particular interest to
assess perfusion in these pathologies. We assessed paediatric tumour perfusion using
both arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC) on
a 3T TX Philips Achieva scanner. Blood flow maps were produced for both
techniques where good qualitative agreement was found illustrated by strong,
significant pixel-by-pixel correlations.
We found that tumour blood flow measured by ASL and DSC significantly
correlated (ρ = 0.714, P = 0.047) suggesting ASL can be used instead of DSC for
this measurement.
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