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Abstract #2466

Cerebral blood flow measurements correlate well in paediatric brain tumour patients using ASL- and DSC-MRI

Jan Novak1,2, Stephanie Withey1,2, Lesley MacPherson3, and Andrew Peet1,2

1Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom, 2Oncology, Birmingham Children's Hospital, Birmingham, United Kingdom, 3Radiology, Birmingham Children's Hospital, Birmingham, United Kingdom

Low grade paediatric brain tumours are increasingly being targeted by anti-vasculature therapies. It is therefore of particular interest to assess perfusion in these pathologies. We assessed paediatric tumour perfusion using both arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC) on a 3T TX Philips Achieva scanner. Blood flow maps were produced for both techniques where good qualitative agreement was found illustrated by strong, significant pixel-by-pixel correlations. We found that tumour blood flow measured by ASL and DSC significantly correlated (ρ = 0.714, P = 0.047) suggesting ASL can be used instead of DSC for this measurement.

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