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Abstract #2476

Reproducibility of quantitative magnetization transfer imaging of the healthy breast at 3T

Lori R. Arlinghaus1, Richard D. Dortch1,2, Jennifer G. Whisenant2, Hakmook Kang3, and Thomas E. Yankeelov1,2

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3Department of Biostatistics, Vanderbilt University, Nashville, TN, United States

Magnetization transfer (MT) imaging is sensitive to changes in the macromolecular content of tissue and is, therefore, gaining increased attention as a noninvasive approach to probe the complex tumor environment in cancer. The ratio of macromolecular protons to the protons in the free water pool, or pool size ratio (PSR), can be quantified with quantitative MT (qMT) imaging and may be useful for detection of changes in macromolecular content early in the course of treatment. In this study, we explore the repeatability of PSR measurements in healthy breast fibroglandular tissue at 3T to serve as a benchmark for future longitudinal studies of breast cancer treatment.

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