Abstract #2480

Proton Density Water Fraction as a Measurement of Breast Fibroglandular Tissue Volume and Concentration

Roberta M Strigel^1,2,3, Leah Henze Bancroft², Diego Hernando¹, and Scott B Reeder^1,2,3,4,5,6

¹Radiology, University of Wisconsin, Madison, WI, United States, ²Medical Physics, University of Wisconsin, Madison, WI, United States, ³Carbone Cancer Center, University of Wisconsin, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin, Madison, WI, United States, ⁶Medicine, University of Wisconsin, Madison, WI, United States

Elevated breast density confers an increased risk for breast cancer. Accurate and precise measurement of the amount of fibroglandular breast tissue has potential to serve as a quantitative imaging biomarker of risk for the development of breast cancer. In this work we introduce novel, confounder corrected chemical-shift encoded (CSE)-MRI techniques to measure the proton density water fraction (PDWF). Estimation of PDWF with CSE-MRI addresses potential confounders that negatively impact accuracy, precision, and reproducibility, enabling protocol independent quantification of the volume and concentration of fibroglandular tissue in the breast.

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