Abstract #2485

3D MRI Breast Density Change in Women with Hormonal Positive Breast Cancer Following Adjuvant Hormonal Therapy

Yoon Jung Choi¹, Jeon-Hor Chen^2,3, Shunshan Li², Po-Han Chen⁴, Pei-Yu Liu⁴, Inyoung Youn¹, and Min-Ying Su²

¹Department of Radiology, Kangbuk Samsung Hospital, Seoul, Korea, Republic of, ²Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States, ³Department of Radiology, Eda Hospital and I-Shou University, Kaohsiung, Taiwan, ⁴Department of Medical Imaging, China Medical University, Taichung, Taiwan

Hormonal regimens may affect breast tissue with the change of breast volume or composition. This study was to apply a well-established breast and fibroglandular tissue segmentation method to analyze the density changes in patients receiving adjuvant hormonal therapy. The results showed that pre-menopausal women had a higher density reduction, presumably due to their more abundant fibroglandular tissues that can be decreased, but a high variation was observed. The density reduction assessed by 3D MRI may be used as a surrogate marker to correlate with metabolic genotyping, and further used in combination to better predict patient’s prognosis.

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