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Abstract #2554

Non-contrast-enhanced MRA using Velocity-sensitised, Acceleration-sensitised and Combined Sensitisation with Fast-Spin-Echo Readout

Andrew Nicholas Priest1, Ian G Murphy1, and David John Lomas1

1Radiology, Addenbrookes Hospital and Cambridge University, Cambridge, United Kingdom

This work develops an NCE-MRA technique based on the flow-sensitised dephasing (FSD) method but using a fast-spin echo (FSE) readout to avoid off-resonance artifacts and allow a larger field of view. The flow-preparation module may be velocity-sensitised, acceleration-sensitised or mixed velocity-and-acceleration-sensitised. The FSE readout allows these approaches to be combined with additional flow sensitisation by ‘adaptive refocus’ which reduces the refocusing flip angle in systole. These approaches performed well in healthy volunteers, in particular the velocity-sensitisation and mixed-sensitisation approaches. Adding adaptive refocus increased venous contamination and thus reduced the arterial image quality. Future work will evaluate these methods in patients.

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