Abstract #2576

Structural and functional evaluation (SaFE)-MRI of peripheral artery disease (PAD) using 3D double-echo steady-state and time-resolved velocimetry

Michael Langham¹, Benoit Desjardins¹, Erin Englund¹, Emile R Mohler, III², Thomas Floyd³, Jamal J Derakshan¹, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Anesthesiology, SUNY Stony Brook, Stony Brook, NY, United States

An alternative unenhanced structural and functional evaluation (SaFE-MRI) MRI is proposed and described for assessing peripheral artery disease (PAD). The SaFE-MRI protocol interleaves 3D double-echo steady-state (DESS) acquisition and velocity mapping at each station. In SaFE-MRI velocity maps in all major conduit arteries (from abdominal aorta to runoff arteries) serve as a “road map” for locating hemodynamically significant stenoses and gray- and black-blood images are used to grade stenoses and detect vascular calcium. Initial results in patients with PAD agree with the finding from CTA and CE-MRA examinations as well as pressure volume recordings.

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