Abstract #2602

4D Flow MRI for the Evaluation of Vasodilation in Patients with Sickle Cell Disease

Lena Václavů¹, Bart J Biemond², John C Wood³, Henk Mutsaerts⁴, Charles BLM Majoie¹, Ed van Bavel⁵, Aart J Nederveen¹, and Pim van Ooij¹

¹Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, ³Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁴Sunnybrook Research Institute, Toronto, ON, Canada, ⁵Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

We employed 4D Flow MRI in patients with Sickle Cell Disease. 4D Flow MRI is a non-invasive technique allowing blood flow velocity measurements and estimation of WSS. We investigated dynamic changes in velocity, WSS and vessel diameter in the anterior circulation of the Circle of Willis (CoW) in response to a vasodilator (acetazolamide [ACZ]). We found that velocity and WSS increased in the CoW after administration of the vasodilator ACZ, as measured with 4D flow MRI. The change in velocity after administration of ACZ was larger in controls than in patients.

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