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Abstract #2606

Measurement of extracellular volume fraction and blood flow from dynamic contrast enhanced myocardial perfusion images applied in non-ischemic cardiomyopathy

Yoon-Chul Kim1, Sung Mok Kim1, Sung-Ji Park1, and Yeon Hyeon Choe1

1Samsung Medical Center, Sungkyunkwan Univ. School of Medicine, Seoul, Korea, Republic of

Recently there have been several studies of estimation of extracellular volume (ECV) fraction from dynamic contrast enhanced (DCE) myocardial perfusion images using a distributed parameter (DP) model. We apply the DP model to DCE perfusion images acquired from a standard stress perfusion protocol, and demonstrate ECV measurements in aortic stenosis (AS) patients (n=13) and hypertrophic cardiomyopathy (HCM) patients (n=11). Preliminary results from sector-wise analysis indicate 1) higher mean ECV values in HCM patients than normal volunteers and AS patients and 2) lower mean blood flow values in AS and HCM patients than those in normal volunteers.

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