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Abstract #2608

Comparison of myocardial perfusion and permeability estimates from dynamic contrast-enhanced MRI with three quantitative analysis methods

Wang Jing1, Yudong Zhang2, Yang Fan3, HaiBin Shi2, and Xiaoyan Liu1

1Center for Medical Device Evaluation, CFDA, Beijing, China, People's Republic of, 2Department of Radiology, the First Affiliated Hospital with Nanjing Medical University Nanjing, Nanjing, China, People's Republic of, 3GE Healthcare, MR Research China, Beijing, China, People's Republic of

This study compares three methods for quantitatively analyzing dynamic contrast-enhanced MRI datasets for the extraction of myocardial perfusion, permeability, and other hemodynamic parameters. The two-compartment exchange model and the adiabatic approximation to the tissue homogeneity models are compared with reference to model-free deconvolution. The goal was to determine if these three models could reliably estimate hemodynamic parameters and be able to distinguish between normal patients and those with hypertrophic cardiomyopathy. Results demonstrate that all three methods yield consistent estimates for perfusion, blood volume, and mean transit times, and that these parameters were significantly different for the hypertrophic heart.

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