Abstract #2615

Effect of exercise on skeletal muscle and cardiac function in mouse models of Duchenne muscular dystrophy

Bauke Kogelman¹, Margriet Hulsker², Christa Tanganyika-de Winter², Ralf Werring², Annemieke Aartsma-Rus², Maaike van Putten², and Louise van der Weerd^1,2

¹Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands

Duchenne muscular dystrophy is affecting skeletal and cardiac muscle tissue, due to non-functional dystrophin protein. Potential therapies restore dystrophin expression in skeletal muscle, while cardiac muscle is more difficult to target. To elucidate whether exercise is beneficial or disadvantageous for (cardio)myopathy, we subjected several mouse models, mdx (0% dystrophin), mdx-Xist∆hs (varying dystrophin levels), Bl10-WT and Xist-WT wild type mice (100% dystrophin) to low intensity or no exercise. Results showed that low dystrophin levels improve skeletal muscle and cardiac function and suggest that low intensity exercise is beneficial for skeletal and cardiac muscle function in both dystrophic and wild type mice.

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