Abstract #2636

MR T1ρ imaging study on normal-appearing brain in patients with nasopharyngeal carcinoma after radiotherapy

Xiang Xiao¹, Yikai Xu¹, Yuankui Wu¹, Yingjie Mei², and Queenie Chan³

¹Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, ²Philips Healthcare, Guangzhou, China, People's Republic of, ³Philips Healthcare, HongKong, China, People's Republic of

Radiation induced encephalopathy is one of the most serious complications of radiotherapy (RT) for treatment of nasopharyngeal carcinoma (NPC). In order to detect early radiation-induced changes in gray matter (GM) and white matter (WM) of NPC patients after RT, we recruited NPC patients before RT and after RT with normal-appearing brain for MR T1ρ examination. We found abnormal microstructure changes of WM had already happened in NPC patients after RT even when routine MRI findings are negative. MR T1ρ imaging can be used to detect early radiation-induced changes of WM following RT for NPC patients.

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