Abstract #2640

Assessment of anti-angiogenic efficacy of targeted ECO/siHIF-1α nanoparticles with DCE-MRI and a biodegradable macromolecular contrast agent

Anthony Malamas¹ and Zheng-Rong Lu¹

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

To apply DCE-MRI with a biodegradable macromolecular contrast agent in assessment of the efficacy of targeted ECO/siRNA nanoparticles for silencing HIF-1α expression for cancer therapy in a mouse colon cancer model. DCE-MRI non-invasively revealed that the treatment resulted in over 70% reduction in average tumor blood flow (Fp), permeability-surface area product (PS), and plasma volume fraction (Vp) in the treatment group as compared to the saline control group (p < 0.05). The treatment was effective to inhibit tumor angiogenesis and proliferation.

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