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Abstract #2649

Integrating dynamic contrast-enhanced magnetic resonance imaging and diffusion kurtosis imaging for neoadjuvant chemotherapy assessment in nasopharyngeal carcinoma

Dechun Zheng1, Yunbin Chen1, Meng Liu1, Qiuyuan Yue1, Xiaoxiao Zhang1, Hao Lin1, Xiangyi Liu1, Wang Ren1, Weibo Chen2, and Queenie Chan3

1Radiology, Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of, 2Philips Healthcare, Shanghai, China, People's Republic of, 3Philips Healthcare, Hong Kong, Hong Kong

DKI is an emerging technique and shows advantage than traditional DWI. Prior DCE-MRI studies suggested it had utility in early monitoring radiotherapy and chemotherapy sensitivity in anti-tumor treatment. However, there are a few studies investigated whether a combination of multi-modalities functional MRI techniques could improve diagnostic efficacy for prediction of anti-tumor outcome. This study enrolled 53 patients who received both DCE-MRI and DKI exams during NAC courses and suggested there were collaboration between DCE-MRI and DKI to early monitor NAC treatments in NPC. In addition, two NAC cycles is a better time point to non-invasive assess NAC response using fMRI.

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