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Abstract #2652

MRI/MRS–based assessment of lipid metabolism: a new tool for better detection and characterization of breast tumors?

Ileana Hancu1, Elizabeth Morris2, Christopher Sevinsky1, Fiona Ginty1, and Sunitha Thakur2

1GE Global Research Center, Niskayuna, NY, United States, 2Memorial Sloan Kettering Cancer Center, New York City, NY, United States

Differential expression of lipid metabolism genes was recently reported in breast cancer patients. In this pilot study, single voxel MRS data was used to assess the spatial and spectral lipid profile of normal volunteers and subjects undergoing neo-adjuvant chemotherapy. Statistically significant differences in lipid profiles from different voxels in single volunteers and between volunteers were found. Moreover, some lipid peak ratios provided good tumor/normal tissue separation. MRI/MRS-based profiling of lipid metabolism may provide a unique tool for better breast cancer tumor detection and characterization.

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