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Abstract #2692

Non-Contrast MR Angiography with Arterial Spin Labeling: Initial Experience in Pediatric Patients With a 3D Spiral pCASL and CINEMA Protocol

Amber Pokorney1, Niccolo Stefani2, Zhiqiang Li3, Jonathan M. Chia2, John Condie4, Houchun Harry Hu1, and Jeffrey H. Miller1

1Radiology, Phoenix Children's Hospital, Phoenix, AZ, United States, 2Philips, North America, Cleveland, OH, United States, 3Barrow Neurological Institute, Phoenix, AZ, United States, 4Neurology, Phoenix Children's Hospital, Phoenix, AZ, United States

This pilot clinical study evaluates the diagnostic utility of a 3D spiral pCASL approach and a 3D dynamic PASL pulse sequence (i.e., CINEMA) in evaluating the neurovasculature in pediatric patients. With increasing recent concerns over the possible deposition of Gadolinium in the brain, a viable clinical protocol that can supplant traditional contrast-enhanced MR angiography is particularly relevant to the pediatric population. Our clinical results in patients ranging from 1 year of age to adolescents demonstrate that both 3D spiral pCASL and dynamic PASL are robust approaches and yield diagnostically useful information that supports clinical findings from conventional TOF angiography.

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