Abstract #2692

Non-Contrast MR Angiography with Arterial Spin Labeling: Initial Experience in Pediatric Patients With a 3D Spiral pCASL and CINEMA Protocol

Amber Pokorney¹, Niccolo Stefani², Zhiqiang Li³, Jonathan M. Chia², John Condie⁴, Houchun Harry Hu¹, and Jeffrey H. Miller¹

¹Radiology, Phoenix Children's Hospital, Phoenix, AZ, United States, ²Philips, North America, Cleveland, OH, United States, ³Barrow Neurological Institute, Phoenix, AZ, United States, ⁴Neurology, Phoenix Children's Hospital, Phoenix, AZ, United States

This pilot clinical study evaluates the diagnostic utility of a 3D spiral pCASL approach and a 3D dynamic PASL pulse sequence (i.e., CINEMA) in evaluating the neurovasculature in pediatric patients. With increasing recent concerns over the possible deposition of Gadolinium in the brain, a viable clinical protocol that can supplant traditional contrast-enhanced MR angiography is particularly relevant to the pediatric population. Our clinical results in patients ranging from 1 year of age to adolescents demonstrate that both 3D spiral pCASL and dynamic PASL are robust approaches and yield diagnostically useful information that supports clinical findings from conventional TOF angiography.

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