Abstract #2700

4D flow MRI-derived Wall Shear Stress Correlates with Vessel Wall Thickness: Atlases of the Carotid Bifurcation

Pim van Ooij¹, Merih Cibis², Wouter V. Potters¹, Oscar H Franco³, Meike Vernooij⁴, Aad van der Lugt⁴, Frank J Gijsen², Jolanda J Wentzel², and Aart J Nederveen¹

¹Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Biomedical Engineering, Erasmus MC, Rotterdam, Netherlands, ³Epidemiology, Erasmus MC, Rotterdam, Netherlands, ⁴Radiology, Erasmus MC, Rotterdam, Netherlands

The purpose of this study is to investigate if, already in early disease, a correlation exists between wall thickness (WT) and wall shear stress (WSS) in the carotid bifurcation. Eleven subjects with plaques in the left carotid arteries underwent 3D-flow-MRI and proton-density-weighted-EPI for WSS and WT quantification, respectively. Relationships between WT and WSS were investigated on an individual basis and using cohort-averaged maps (atlases). Spearman’s ρ averaged over all subjects was -0.28, which was significantly different from 0 (p<0.001). For the atlases, ρ was -0.66 (p<0.001). The atlas approach facilitates more statistical power to show that wall thickening occurs in low WSS regions.

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