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Abstract #2700

4D flow MRI-derived Wall Shear Stress Correlates with Vessel Wall Thickness: Atlases of the Carotid Bifurcation

Pim van Ooij1, Merih Cibis2, Wouter V. Potters1, Oscar H Franco3, Meike Vernooij4, Aad van der Lugt4, Frank J Gijsen2, Jolanda J Wentzel2, and Aart J Nederveen1

1Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Biomedical Engineering, Erasmus MC, Rotterdam, Netherlands, 3Epidemiology, Erasmus MC, Rotterdam, Netherlands, 4Radiology, Erasmus MC, Rotterdam, Netherlands

The purpose of this study is to investigate if, already in early disease, a correlation exists between wall thickness (WT) and wall shear stress (WSS) in the carotid bifurcation. Eleven subjects with plaques in the left carotid arteries underwent 3D-flow-MRI and proton-density-weighted-EPI for WSS and WT quantification, respectively. Relationships between WT and WSS were investigated on an individual basis and using cohort-averaged maps (atlases). Spearman’s ρ averaged over all subjects was -0.28, which was significantly different from 0 (p<0.001). For the atlases, ρ was -0.66 (p<0.001). The atlas approach facilitates more statistical power to show that wall thickening occurs in low WSS regions.

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