Abstract #2721

Diagnostic Performance of Maximum Slope as a Novel Kinetic Parameters in High Resolution Ultrafast Dynamic Contrast Enhanced Breast MRI using KWIC

Akane Ohashi¹, Masako Kataoka¹, Syotaro Kanao¹, Mami Iima¹, Onishi Natsuko¹, Makiko Kawai¹, Masakazu Toi², Elizabeth Weiland³, and Kaori Togashi¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Kyoto Univercity Graduate School of Medicine, Kyoto, Japan, ²Breast Surgery, Kyoto Univercity, Kyoto, Japan, ³Siemens Healthcare GmbH, Erlangen, Germany

Maximum slope (MS) is a kinetic parameter obtained from the very early phase of ultrafast DCE MRI. Diagnostic performance of MS in breast lesions were compared to washout index (WI), a conventional semi-quantitative kinetic parameters obtained from standard DCE MRI. Ultrafast DCE MRI was obtained using KWIC and analyzed by TWIST Breast Viewer. MS demonstrated significantly higher AUC (0.91) than WI (0.80, p=0.03) with fewer false positive cases of fibrocystic changes than WI. MS is a promising kinetic parameters that provides information complimentary to WI in diagnosing breast lesions.

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