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Abstract #2721

Diagnostic Performance of Maximum Slope as a Novel Kinetic Parameters in High Resolution Ultrafast Dynamic Contrast Enhanced Breast MRI using KWIC

Akane Ohashi1, Masako Kataoka1, Syotaro Kanao1, Mami Iima1, Onishi Natsuko1, Makiko Kawai1, Masakazu Toi2, Elizabeth Weiland3, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Kyoto Univercity Graduate School of Medicine, Kyoto, Japan, 2Breast Surgery, Kyoto Univercity, Kyoto, Japan, 3Siemens Healthcare GmbH, Erlangen, Germany

Maximum slope (MS) is a kinetic parameter obtained from the very early phase of ultrafast DCE MRI. Diagnostic performance of MS in breast lesions were compared to washout index (WI), a conventional semi-quantitative kinetic parameters obtained from standard DCE MRI. Ultrafast DCE MRI was obtained using KWIC and analyzed by TWIST Breast Viewer. MS demonstrated significantly higher AUC (0.91) than WI (0.80, p=0.03) with fewer false positive cases of fibrocystic changes than WI. MS is a promising kinetic parameters that provides information complimentary to WI in diagnosing breast lesions.

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