Using MRI to assess changes in distribution and leakage of contrast media in murine mammary ducts after intra-ductal injection: intact ducts vs. ducts with in situ cancer
Erica Markiewicz1, Xiaobing Fan1, Devkumar Mustafi1, Marta Zamora1, Suzanne D. Conzen2, and Gregory S Karczmar1
1Radiology, University of Chicago, Chicago, IL, United States, 2Medicine, Hematology/Oncology, University of Chicago, Chicago, IL, United States
Contrast media injected directly into mammary
ducts clearly shows mammary gland structure with 3D-MRI. Development of in situ cancer causes changes in the leakage
rates and contrast agent distribution in ductal lumens and surrounding tissue. Differences
we describe here between FVB/N mice and the SV40Tag mammary cancer mouse model,
indicate that in situ cancer
significantly changes the permeability of the ductal epithelium. Information
gained from imaging these glands following intra-ductal injection can be used
to develop new MRI-detectable biomarkers for early detection of in situ cancer, improve understanding of
mammary cancer biology, and guide the design of new therapy.
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