Abstract #2751

Quantitative susceptibility mapping of prostate cancer xenografts

Kofi Deh¹, Marjan Zaman¹, Padraic O'Malley¹, Richard Lee¹, Pascal Spincemaille¹, and Yi Wang¹

¹Weill Cornell Medicine, New York, NY, United States

Quantitative susceptibility mapping (QSM) is a recently developed technique for quantifying magnetic susceptibility and it may be useful in quantifying super-paramagnetic iron oxide (SPIO) nanoparticles for prostate cancer therapy. Previously, researchers have been hampered in extending the use of this technique to cancers outside the brain because of problems such as chemical shift and a large dynamic susceptibility range. Recently developed algorithms, however, allow us to overcome these problems and we demonstrate their use for quantifying SPIO in a prostate cancer xenograft model for magnetic hyperthermia.

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