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Abstract #2787

Assessment of radiation damaged mouse lungs using perfluorohexane liquid MRI.

Alexandre A Khrapitchev1, James R Larkin1, Stavros Melemenidis1, Peter E Thelwall2, and Nicola R Sibson1

1Department of Oncology, University of Oxford, Oxford, United Kingdom, 2Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

The imaging of lungs with MRI is difficult owing to low proton density. Imaging with hyperpolarized noble gases has overcome some of these limitations but at great expense and effort. We have investigated damage caused by radiation of mouse lungs using 19F MRI of perfluorohexane – a cheap biocompatible liquid at room temperature. Using lungs filled with perfluorohexane, we were able to obtain high resolution scans with comparable SNRs to hyperpolarized xenon imaging and high resolution. These bright and stable lung images provide a very sensitive tool to monitor the lung damage development.

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