Abstract #2787

Assessment of radiation damaged mouse lungs using perfluorohexane liquid MRI.

Alexandre A Khrapitchev¹, James R Larkin¹, Stavros Melemenidis¹, Peter E Thelwall², and Nicola R Sibson¹

¹Department of Oncology, University of Oxford, Oxford, United Kingdom, ²Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom

The imaging of lungs with MRI is difficult owing to low proton density. Imaging with hyperpolarized noble gases has overcome some of these limitations but at great expense and effort. We have investigated damage caused by radiation of mouse lungs using ¹⁹F MRI of perfluorohexane – a cheap biocompatible liquid at room temperature. Using lungs filled with perfluorohexane, we were able to obtain high resolution scans with comparable SNRs to hyperpolarized xenon imaging and high resolution. These bright and stable lung images provide a very sensitive tool to monitor the lung damage development.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.