Abstract #2795

T2*-weighted imaging and DCE-MRI as complementary tools to characterize the continuous process of radionecrosis and neovascularization

Jérémie P. Fouquet¹, Julie Constanzo¹, Laurence Masson-Côté^1,2, Luc Tremblay¹, Philippe Sarret³, Sameh Geha⁴, Kevin Whittingstall⁵, Benoit Paquette¹, and Martin Lepage¹

¹Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Service of Radiation Oncology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ³Department of Pharmacology-Physiology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Department of Pathology, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁵Department of Diagnostic Radiology, Université de Sherbrooke, Sherbrooke, QC, Canada

Radiation dose delivered to healthy tissues during brain tumors radiosurgery can cause important side effects. We imaged an animal model of brain irradiation with DCE-MRI and T2*-weighted imaging at different time points after treatment. DCE-MRI allowed the discrimination of areas with high vessel permeability and necrotic regions. T2*-weighted imaging enabled the visualization of a necrotic core and micro-lesions at its periphery. Micro-lesions were initially co-localized with permeable vessels and later evolved into necrosis. Together, DCE-MRI and T2*-weighted images provided a coherent picture on the phenomena involved in radionecrosis progression, which could help in the management of associated problems.

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