Abstract #2797

Response Assessment to Tumor Treating Fields in Patients with Glioblastoma using Physiologic and Metabolic MR Imaging

Sanjeev Chawla¹, Sumei Wang¹, Gaurav Verma¹, Aaron Skolnik¹, Sulaiman Sheriff², Katelyn M Reilly¹, Lisa Desiderio¹, Andrew Maudsley², Steven Brem³, Katherine Peters⁴, Harish Poptani⁵, and Suyash Mohan¹

¹Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ²Radiology, University of Miami, Miami, FL, United States, ³Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ⁴Neurology, Duke University Medical Center, Durham, NC, United States, ⁵Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, United Kingdom

Tumor treating fields (TTFields) are a novel antimitotic treatment modality for treatment of patients with glioblastoma (GBM). To assess response to TTFields, 4 GBM patients underwent diffusion, perfusion and 3D-echo-planar spectroscopic imaging prior to initiation of TTFields and at one and two month follow-up periods. A trend towards increased MD and a decrease in FA and rCBV_max was noted in most patients at 2-month relative to baseline indicating inhibited tumor growth and vascularity. Cho/Cr values did not exhibit any trend probably due to heterogeneity in response. These preliminary data indicate the potential of advanced MR imaging in assessing response to TTFields.

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