Abstract #2799

Early Assessment of Antiangiogenic Effects of Sorafenib using IVIM in Mouse Model with Hepatocellular Carcinoma

Yong Zhang¹, Bing Wu¹, Xin Chen², and Zaiyi Liu²

¹GE Healthcare MR Research China, Beijing, China, People's Republic of, ²Radiology, Guangdong General Hospital, Guangzhou, China, People's Republic of

Antiangiogenic therapy is efficient to treat hypervascular tumor such as hepatocelluar carcinoma (HCC). Unlike chemotherapy and radiation therapy, tumor dimension doesn’t change in its early phase. Hence traditional reponse criteria based on morphological change fails to early assess the therapeutic response of antiangiogenic treatment. This study used intravoxel incoherent motion (IVIM) theory to separate perfusion and diffusion characteristics in HCC over sereval time points after antiangiogenic Sorafenib administration. It was found that IVIM-derived pure diffusivity and pseudo-diffusivity were able to detect the microvascular collapse and cellular edema in HCC at early phase of antiangiogenic medication.

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