Abstract #2810

Early detection of changes in phospholipid metabolism during neoadjuvant chemotherapy using phosphorus magnetic resonance spectroscopy at 7 tesla

Erwin Krikken¹, Wybe J.M. van der Kemp¹, Hanneke W.M. van Laarhoven², Dennis W.J. Klomp¹, and Jannie P. Wijnen¹

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Medical Oncology, Academic Medical Center Amsterdam, Amsterdam, Netherlands

Neoadjuvant chemotherapy plays an important role in the treatment of breast cancer patients. During chemotherapy, the phospholipid metabolism changes which can be measured by ³¹P-MRS at 7 tesla. Eight patients were examined, using the AMESING sequence to receive metabolic signals in the tumor. The ³¹P-MRS data were analyzed on group level, which enables the detection of changes the levels of phospholipid metabolites in an early stage of the treatment, directly after the first cycle of chemotherapy.

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