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Abstract #2810

Early detection of changes in phospholipid metabolism during neoadjuvant chemotherapy using phosphorus magnetic resonance spectroscopy at 7 tesla

Erwin Krikken1, Wybe J.M. van der Kemp1, Hanneke W.M. van Laarhoven2, Dennis W.J. Klomp1, and Jannie P. Wijnen1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Medical Oncology, Academic Medical Center Amsterdam, Amsterdam, Netherlands

Neoadjuvant chemotherapy plays an important role in the treatment of breast cancer patients. During chemotherapy, the phospholipid metabolism changes which can be measured by 31P-MRS at 7 tesla. Eight patients were examined, using the AMESING sequence to receive metabolic signals in the tumor. The 31P-MRS data were analyzed on group level, which enables the detection of changes the levels of phospholipid metabolites in an early stage of the treatment, directly after the first cycle of chemotherapy.

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