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Abstract #2844

Simultaneous Quantification of Blood Vessel Caliber and Oxygenation via Multi-Voxel Joint Utilization of Magnitude and Phase (MV-JUMP)

Patrick McDaniel1, Berkin Bilgic2, Audrey Fan3, Jeffrey Stout4, and Elfar Adalsteinsson1,4

1Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States, 2Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Richard M Lucas Service Center for Imaging, Stanford University, Stanford, CA, United States, 4Health Sciences and Technology, Harvard/MIT, Cambridge, MA, United States

Accurate, quantitative determination of blood vessel oxygenation and caliber from GRE data would be useful for assessing local perfusion and oxygen consumption. However, partial-volume effects confound both measurements. Vessel edges are blurred and discretized, hampering assessment of vessel size. Oxygenation can be measured from GRE phase, but partial-volume effects with other tissues often contaminate these measurements. In this work, we present a novel approach that simultaneously obtains accurate measurements of vessel caliber and oxygenation state for vessels nearly parallel to B0. This approach is demonstrated in numerical and in vivo experiments.

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