Abstract #2855

WHOLE-BODY QUANTITATIVE SUSCEPTIBILITY MAPPING IN HEALTHY SUBJECTS AND IN PATIENTS WITH IRON OVERLOAD

Samir D. Sharma¹, Jens-Peter Kühn², Marie-Luise Kromrey², Scott B. Reeder^1,3, and Diego Hernando¹

¹Radiology, University of Wisconsin - Madison, Madison, WI, United States, ²Experimental Radiology, Greifswald University, Greifswald, Germany, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Magnetic susceptibility is a fundamental property of all tissues. The presence of biomaterials (e.g. iron, gadolinium) changes the susceptibility of the tissue in a direct and well-understood manner, allowing quantification of biomaterial concentration. Quantitative susceptibility mapping (QSM) techniques have been developed, largely to investigate iron and calcium deposits in the brain. The development and application of whole-body QSM may enable improved characterization and quantification of tissue pathophysiology based on a fundamental property of tissue. Thus, the purpose of this work was to develop and demonstrate the feasibility of whole-body QSM in healthy subjects and in patients with suspected iron overload.

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