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Abstract #2872

Comparison of pseudo-continuous arterial spin labeling with [15O]-water PET at baseline and after Diamox: a simultaneous PET-MRI study

Audrey Fan1, Praveen Gulaka1, Mohammad Mehdi Khalighi2, Bin Shen1, Aileen Hoehne1, Prachi Singh1, Jun H Park1, Dawn Holley1, Frederick T Chin1, and Greg Zaharchuk1

1Radiology, Stanford University, Stanford, CA, United States, 2Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

The ability to noninvasively image cerebral blood flow (CBF) would help with assessment of many cerebrovascular disorders including stroke. We compared simultaneous PET-MRI measurements of CBF by arterial spin labeling MRI and the [15O]-water PET reference standard in healthy volunteers. ASL and PET revealed similar spatial distributions of perfusion in the brain and reliably detected CBF augmentation due to Diamox administration. ASL MRI also demonstrated lower scan-rescan coefficient of variation across the gray matter relative to PET. Going forward, we will perform kinetic modeling of absolute CBF from [15O]-water PET and consider potentially different radiotracer arterial input functions (derived from the PET-MRI images themselves) that occur in different brain perfusion states.

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