Abstract #2899

Imaging the pH by means of CEST-responsive iopamidol: normal and AKI model studies

Wei Hu¹, Zhuozhi Dai¹, Zhiwei Shen¹, Yuanyu Shen¹, Xiangyong Tang¹, Zhiyan Zhang¹, Gang Xiao², Phillip Zhe Sun³, and Renhua Wu¹

¹2nd Affilicated Hospital, Shantou University Medical College, Shantou, China, People's Republic of, ²Hanshan Normal University, Chao zhou, China, People's Republic of, ³Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

The promising imaging technique of chemical exchange saturation transfer (CEST) MRI, which is sensitive to microenvironment properties including pH, metabolites, temperature, metal ions, and enzymatic activities, has been increasingly applied in vivo such as acute ischemia, infection and cancer. The aim of this work was to observe the differentiation between normal and acute kidney injury (AKI) using echo-planar imaging sequence (EPI) as well as the sensitive ratiometric methods under 7T magnetic field.

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