Abstract #2901

GluCEST imaging of spinal cord in a mouse model of Friedreich ataxia

Jérémy Pépin^1,2, Françoise Piguet^3,4,5,6, Hélène Puccio^3,4,5,6, and Julien Flament^1,7

¹CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, ²CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France, ³Department of Translational Medecine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, ⁴INSERM U596, Illkirch, France, ⁵CNRS UMR7104, Illkirch, France, ⁶Université de Strasbourg, Strasbourg, France, ⁷INSERM UMS 27, Fontenay-aux-Roses, France

Friedreich Ataxia (FA) is the most common form of recessive inherited ataxia which induces severe neurological disabilities and reduced life expectancy. As glutamate has been shown to be a potential biomarker of neurodegenerative diseases, we used Chemical Exchange Saturation Transfer imaging of glutamate (gluCEST) in order to characterize our mouse model of FA and to monitor glutamate alterations in the spinal cord. GluCEST images revealed decrease of glutamate level in FA mouse model compared to control littermates, especially in the lumbar part. These results demonstrate the potential of gluCEST in providing innovative and relevant biomarkers of FA.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.