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Abstract #2912

Ventilation imaging with sulfur hexafluoride in free-breathing mice: initial experience

Marta Tibiletti1, Martin Tschechne1, Andrea Bianchi2, Detlef Stiller2, and Volker Rasche1,3

1Core Facility Small Animal MRI, Ulm University, Ulm, Germany, 2Target Discovery Research, In-vivo imaging laboratory, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany, 3Department of Internal Medicine II, Ulm University, Ulm, Germany

Functional information of the lung is of great importance for staging and monitoring lung disease. Imaging of lung ventilation has been addressed by inhalation of polarized gases like Helium or Xenon. Major limitation of this technique rises from the high costs of equipment and gases. As an efficient alternative to polarized gases, the use of fluorinated gases has been proposed. In pre-clinical application these have always been used in combination with intubation, which does not realistically reflect the ventilation during free breathing. In this contribution the imaging of ventilation in mice with fluorinated gases during free-breathing is addressed.

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