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Abstract #2917

Fast 3D quantitative 1H ventilation imaging of the human lung at 1.5T with SSFP

Orso Pusterla1,2, Grzegorz Bauman1,2, Mark Wielp├╝tz3,4, Claus Heussel3,4, and Oliver Bieri1,2

1Radiological Physics, Dep. of Radiology, University of Basel Hospital, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 3Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany, 4Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany

Monitoring lung ventilation is of great interest to assess pulmonary function and disease progression. Here, a novel, fast, and simple three-dimensional (3D) quantitative in vivo 1H imaging method is introduced, reflecting regional ventilation information. To this end, typically five ultra-fast balanced steady state free precession (ufSSFP) scans are repetitively performed in breath-hold from which a respiratory index map, $$${\gamma}$$$, is derived. The new measure $$${\gamma}$$$ shows high reproducibility in healthy volunteers and high sensitivity to respiratory defects, such as in patients with COPD.

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