Abstract #2917

Fast 3D quantitative 1H ventilation imaging of the human lung at 1.5T with SSFP

Orso Pusterla^1,2, Grzegorz Bauman^1,2, Mark Wielpütz^3,4, Claus Heussel^3,4, and Oliver Bieri^1,2

¹Radiological Physics, Dep. of Radiology, University of Basel Hospital, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany, ⁴Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany

Monitoring lung ventilation is of great interest to assess pulmonary function and disease progression. Here, a novel, fast, and simple three-dimensional (3D) quantitative in vivo ¹H imaging method is introduced, reflecting regional ventilation information. To this end, typically five ultra-fast balanced steady state free precession (ufSSFP) scans are repetitively performed in breath-hold from which a respiratory index map, $$${\gamma}$$$, is derived. The new measure $$${\gamma}$$$ shows high reproducibility in healthy volunteers and high sensitivity to respiratory defects, such as in patients with COPD.

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