Abstract #2930

Improving quantitative Hyperpolarized 129Xe gas exchange MRI in idiopathic pulmonary fibrosis

Scott H. Robertson^1,2, Jennifer Wang¹, Geoffry Schrank¹, Holman P. McAdams³, and Bastiaan Driehuys^1,2,4,5

¹Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³Department of Radiology, Duke University Medical Center, Durham, NC, United Kingdom, ⁴Department of Biomedical Engineering, Duke University, Durham, NC, United States, ⁵Department of Radiology, Duke University Medical Center, Durham, NC, United States

While gas-exchange imaging with ¹²⁹Xe holds great potential for enhancing both the diagnosis and followup of IPF, the quantitative ability of these techniques is currently limited by the SNR and spatial resolution afforded by the limited dissolved-phase signal and highly undersampled acquisition. Here we tune our reconstruction for these challenging conditions, and demonstrate improvements in image quality. We then quantify the loss of gas exchange in the apex and base of the lung and show that there is significantly reduced gas exchange in the basal regions of subjects with IPF relative to healthy controls.

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