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Abstract #2939

Multiparametric functional MR imaging for evaluation of hepatic warm ischemia-reperfusion injury in rabbit models

Qian Ji1, Zhi-Qiang Chu2, Tao Ren1, Pan-Li Zuo3, Thorsten Feiweier4, Andre de Oliveira4, and Wen Shen1

1Radiology, Tianjin First Central Hospital, Tianjin, China, People's Republic of, 2Transplantation, Tianjin First Central Hospital, Tianjin, China, People's Republic of, 3MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, People's Republic of, 4Siemens Healthcare GmbH, Erlangen, Germany

Hepatic warm ischemia-reperfusion injury (WIRI) is clinically relevant in liver transplantation. We undertook this study to determine the feasibility of using IVIM, DTI, and BOLD MR imaging for the characterization of hepatic WIRI. 20 hepatic WIRI models and control rabbits were examined using a 3T clinical MR scanner, which followed by biochemical and histopathological analysis. There were significant differences of Dfast, Dslow, PF, ADC, and R2* values between the two groups. There were significant correlations between MR parameters and biochemical parameters. This indicated that multiparametric functional MR imaging are noninvasive and valuable techniques for assessing the pathophysiologic changes of hepatic WIRI.

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