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Abstract #2948

Value of Whole-Liver Apparent Diffusion Coefficient Histogram Analysis for Quantification of Liver Fibrosis Stages

Zhaoxia Yang1, Xinxing Hu1, Heyue Liang1, Robert Grimm2, Caixia Fu3, Xu Yan4, Hui Liu4, Mengsu Zeng1, and Shengxiang Rao1

1Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, People's Republic of, 2MR Application Predevelopment, Siemens Healthcare, Erlangen, Germany, 3Application department, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, People's Republic of, 4MR Collaboration NE Asia, Siemens Healthcare, Shanghai, China, People's Republic of

Histogram analysis of whole-liver ADC maps was applied for patients with liver fibrosis to assess its diagnostic value and correlation with fibrosis stages achieved from liver biopsy. Our study shows that the mean and the 75th percentile ADC were significantly lower with the increasing grade of liver fibrosis. The median, standard deviation (SD), 5th, 10th, 25th, 90th and 95th percentiles also showed statistical differences among pathological fibrosis grades. In conclusion, histogram analysis of whole-liver ADC maps has a potential value for quantifying liver fibrosis grades.

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