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Abstract #2951

Noninvasive MR diffusion and perfusion analysis of liver fibrosis using comprehensive parameters

qing li1, shuangshuang xie1, yu zhang2, wenjing hou1, yue cheng1, and wen shen1

1Radiology, Tianjin First Center Hospital, Tianjin, China, People's Republic of, 2Philips healthcare, Beijing, China, People's Republic of

This study investigated the value of multi-parametric analysis using MR IVIM, BOLD MRI and DKI for the diagnosis of liver fibrosis. Eight patients with clinically diagnosed liver fibrosis and thirteen healthy control subjects were scanned with DKI, IVIM, BOLD. IVIM derived D*, D, f, DKI derived MD, K value and BOLD derived R2* were compared between the two groups. Our results showed D*, D, f, MD decreased, R2* and K value increased in patients with liver fibrosis, but only D* and D demonstrated significant difference (P<0.05). We therefore conclude D* and D could be useful in the diagnosis of liver fibrosis.

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