Abstract #2959

Correlation of Pre –Treatment Volumetric Apparent Diffusion Coefficient Histogram Analysis of Diffusion Weighted MRI in Rectal Cancer with Post ChemoRadiation Treatment Response and Clinical Outcomes.

Kartik Jhaveri¹, Vijay Chidambaram², James Brierley¹, Bernard Cummings^1,3, Rajesh Bhayana¹, Ravi Menezes¹, Erin Kennedy⁴, and Richard Kirsch⁴

¹UHN,university of Toronto, Toronto, ON, Canada, ²Royal Liverpool Hospital, Liverpool, United Kingdom, ³Toronto, Canada, ⁴Mt.Sinai Hospital,University of Toronto, Toronto, Canada

Rectal cancer patients treated with preoperative chemoradiation therapy with complete treatment response can be considered for individualised therapies such as ‘wait and watch’ avoiding surgery. However this currently can only be definitely identified by postoperative histopathology. Diffusion weighted-MRI has been well correlated to tumor biology and treatment response. Volumetric ADC histogram analysis eliminates errors resulting from tumor heterogeneity and variable diffusivities by including the tumor volume and could provide promise for prediction of treatment response and clinical outcomes,thereby providing means for individualised therapy.

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