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Abstract #2959

Correlation of Pre –Treatment Volumetric Apparent Diffusion Coefficient Histogram Analysis of Diffusion Weighted MRI in Rectal Cancer with Post ChemoRadiation Treatment Response and Clinical Outcomes.

Kartik Jhaveri1, Vijay Chidambaram2, James Brierley1, Bernard Cummings1,3, Rajesh Bhayana1, Ravi Menezes1, Erin Kennedy4, and Richard Kirsch4

1UHN,university of Toronto, Toronto, ON, Canada, 2Royal Liverpool Hospital, Liverpool, United Kingdom, 3Toronto, Canada, 4Mt.Sinai Hospital,University of Toronto, Toronto, Canada

Rectal cancer patients treated with preoperative chemoradiation therapy with complete treatment response can be considered for individualised therapies such as ‘wait and watch’ avoiding surgery. However this currently can only be definitely identified by postoperative histopathology. Diffusion weighted-MRI has been well correlated to tumor biology and treatment response. Volumetric ADC histogram analysis eliminates errors resulting from tumor heterogeneity and variable diffusivities by including the tumor volume and could provide promise for prediction of treatment response and clinical outcomes,thereby providing means for individualised therapy.

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