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Abstract #2961

Spatial registration improves parametric mapping of abdominal MRI and may allow assessment of extent of fibrosis in intestinal lesions of patients with Crohn’s Disease

Elizabeth Li1, Tim Lu1, Alexandre Coimbra1, and Alex de Crespigny 1

1Genentech Inc., South San Francisco, CA, United States

Parametric mapping may provide estimates of extent of fibrosis in Crohn’s Disease (CD) patients but are subject to respiratory and peristaltic motion. Various image registration strategies and their impact on quality and robustness of parametric maps of gain of enhancement (GE) and magnetization transfer ratio (MTR) were compared. Healthy test-retest and CD image datasets were evaluated. Spatial registration improved quality and test-retest reliability of GE and MTR maps. In a limited cohort, extent of fibrosis estimated with GE and MTR maps were correlated. Cross validation of MR enterography-based fibrosis estimates with histological data will be conducted as data becomes available.

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