Abstract #2981

Dynamic multi-echo MRI of rectal cancer: Quantitative tumor R2* analysis predicts lymph node status

Endre Grøvik^1,2, Kathrine Røe Redalen³, Sebastian Meltzer^3,4, Anne Negård⁵, Stein Harald Holmedal⁵, Anne Hansen Ree^3,4, Tryggve Holck Storås¹, Atle Bjørnerud^1,2, and Kjell-Inge Gjesdal⁶

¹The Intervention Centre, Oslo University Hospital, Oslo, Norway, ²Department of Physics, University of Oslo, Oslo, Norway, ³Department of Oncology, Akershus University Hospital, Lørenskog, Norway, ⁴Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Department of Radiology, Akershus University Hospital, Lørenskog, Norway, ⁶Sunnmøre MR klinikk AS, Ålesund, Norway

The purpose was to evaluate the association between the dynamic change in R₂*, obtained from a multi-echo dynamic contrast-based acquisition, and clinicopathologic data in patients with rectal cancer. Twenty patients were examined using a high temporal resolution multi-echo EPI sequence. Dynamic R₂* images were calculated by assuming a mono-exponential dependence of signal change on echo-time, and parametric images representing the maximum peak change in R₂*, ΔR₂*-peak, were generated. Tumor ΔR₂*-peak significantly differentiate between rectal cancer patients with and without nodal metastases (P=0.01), with an area under the ROC curve of 0.94.

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