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Abstract #2981

Dynamic multi-echo MRI of rectal cancer: Quantitative tumor R2* analysis predicts lymph node status

Endre Grøvik1,2, Kathrine Røe Redalen3, Sebastian Meltzer3,4, Anne Negård5, Stein Harald Holmedal5, Anne Hansen Ree3,4, Tryggve Holck Storås1, Atle Bjørnerud1,2, and Kjell-Inge Gjesdal6

1The Intervention Centre, Oslo University Hospital, Oslo, Norway, 2Department of Physics, University of Oslo, Oslo, Norway, 3Department of Oncology, Akershus University Hospital, Lørenskog, Norway, 4Faculty of Medicine, University of Oslo, Oslo, Norway, 5Department of Radiology, Akershus University Hospital, Lørenskog, Norway, 6Sunnmøre MR klinikk AS, Ålesund, Norway

The purpose was to evaluate the association between the dynamic change in R2*, obtained from a multi-echo dynamic contrast-based acquisition, and clinicopathologic data in patients with rectal cancer. Twenty patients were examined using a high temporal resolution multi-echo EPI sequence. Dynamic R2* images were calculated by assuming a mono-exponential dependence of signal change on echo-time, and parametric images representing the maximum peak change in R2*, ΔR2*-peak, were generated. Tumor ΔR2*-peak significantly differentiate between rectal cancer patients with and without nodal metastases (P=0.01), with an area under the ROC curve of 0.94.

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