Abstract #2983

QUANTITATIVE SUSCEPTIBILITY MAPPING OF THE LIVER AND SPLEEN IN SUBJECTS WITH FERUMOXYTOL INJECTION

Samir D. Sharma¹, Timothy J. Colgan¹, Camilo A. Campo¹, Tilman Schubert¹, Utaroh Motosugi², Diego Hernando¹, and Scott B. Reeder^1,3

¹Radiology, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, University of Yamanashi, Yamanashi, Japan, ³Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) agent that is taken up by the reticuloendothelial system where it accumulates in organs such as the liver, spleen, and bone marrow. Given the superparamagnetic properties of ferumoxytol, it may be possible for quantitative susceptibility mapping (QSM) techniques to detect and quantify the concentration of ferumoxytol in these organs. Recent technical developments have demonstrated the feasibility of a QSM technique for magnetic susceptibility mapping of the abdomen. Thus, the purpose of this work was to test the feasibility of QSM to assess the longitudinal changes of ferumoxytol in the liver and spleen.

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